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. 2016 Jul 25;5(10):997–1005. doi: 10.1016/j.molmet.2016.07.001

Figure 3.

Figure 3

SR1001 decreases inflammatory profile in LDL-R−/−mice. Splenocytes from LDL-R−/− mice fed 10 days with a HC diet and treated for one moth with SR1001 (black bar, n = 6) or vehicle (white bar, n = 6) were analyzed by flow cytometry for CD4+ (left panel A), CD8+ (middle panel A) or Th17 (SSC-A/IL-17+) (right panel A). Splenocytes form LDL-R−/− mice fed one month with a HC diet and treated for one moth with SR1001 (black bar n = 6) or vehicle white bar, (n = 6) were analyzed by flow cytometry for Th2 (CD4+ Gata3+ (B, upper right)), Treg (CD4+ FoxP3+ (B, upper left)) or Th17 (CD4+/IL-17+(B, lower left)) or Th1 (CD4+/IFNγ+ (B, lower right)). Plasma form LDL-R−/− mice fed one month with a HC diet and treated for one month with SR1001 (black bar, n = 9) or vehicle (white bar, n = 9) was analyzed by Luminex for pro (IFNγ and IL-17) or anti-inflammatory cytokines (C). *p < 0.05, **p < 0.01.