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. 2016 Jul 25;5(10):997–1005. doi: 10.1016/j.molmet.2016.07.001

Figure 5.

Figure 5

SR1001 decreases plasma cholesterol levels and increases intestinal cholesterol excretion in WT mice. (A) Body weight, food, cholesterol intake and fecal cholesterol excretion of single housed WT mice fed with HC diet for 10 days and then treated with SR1001 (black bar, n = 10) or vehicle (white bar, n = 10) for 3 weeks. (B) Total plasma cholesterol level as quantify in SR1001 (black bar, n = 10) or vehicle (white bar, n = 10) treated animals. Intestinal gene (C) and protein (D) expression of cholesterol excretion. Relative level of ABCG5 protein compare to actin for SR1001 (black bar, n = 4) or vehicle (white bar, n = 4) animals. *p < 0.05.