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. 2016 Sep 22;17:391. doi: 10.1186/s12859-016-1240-1

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Effect of initial solution and scaling. Shading represents 90 % confidence intervals for a loess fit of the data points computed using ggplot2 in R. When scaling was used, this solver option was set to a value of 2 (series of alternating row and column scaling with additional scaling)