Table 1.

Glossary of solution methods

Method	Description
bisectME	Maximizes growth rate μ via binary or golden section search [15]. Uses Quad MINOS to solve LP subproblems in quad precision [10]. Every LP after the first is warm-started using the previous solution.
solveME	Combined solution procedure for the nonlinear growth-rate maximization problem Eq. (1). Uses bisectME to find a feasible estimate μ 0, which is used to compute μ (and all fluxes) to high precision using the Quad MINOS NLP solver.
varyME	Flux variability analysis [16] in quad precision with solver warm-starts [17].