Table 4.

Running time (seconds) for warm-start versus cold-started gene essentiality analysis in quad-precision using Quad MINOS (one LP is run for each reaction at a single growth rate)

Model	Genes	Warm-start	Cold-start	Speed-up
E. coli ME (reduced)	1424	3130.8	58967.4	19×
T. maritima ME [3]	613a	5.26 h	>60 h	12×

^aOnly the 613 genes coding for proteins forming functional complexes were tested for essentiality