Fig. 4.

Alantolactone suppressed primary AML but not normal colony formation after 14 days in MethoCult H4434. a Alantolactone dramatically reduced the number of CFUs in primary AML cells from eight AML specimens with a dose-dependent manner. b The representative microscopy images of CFUs in primary AML cells were shown. c Alantolactone showed little effect on the CFUs in normal hematopoietic cells and Ara-C treatment led to notable reduction of colonies from normal donors. d The representative microscopy images of CFUs in normal hematopoietic cells were shown. *P < 0.05, **P < 0.01, ***P < 0.0001