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. 2016 Sep 23;20:273. doi: 10.1186/s13054-016-1422-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Sites of action of prothrombin complex concentrates, nonvitamin K antagonist oral anticoagulants, and warfarin on the coagulation cascade. Blue boxes indicate factors that are present in 3 F- and 4 F-PCCs; the red box indicates factor present in 4 F-PCCs. 3 F-PCC 3-factor prothrombin complex concentrate, 4 F-PCC 4-factor prothrombin complex concentrate