Table 1.
Transcriptome analysis of neurotrophin signaling in cultured human exocrine tissue
| Upregulated | Down regulated | ||||
|---|---|---|---|---|---|
| Symbol | Fold | Symbol | Fold | Symbol | Fold |
| NTRK2 | 277.1 | IL6 | 36.4 | EIF4EBP1 | 2.3 |
| VAV3 | 187.6 | KCNN2 | 28.8 | MYC | 2.3 |
| NCAM1 | 184.0 | MEF2C | 19.2 | SHC1 | 2.3 |
| BCL2 | 42.1 | NRG4 | 18.4 | RGS19 | 2.2 |
| CCND1 | 22.5 | GRIA3 | 17.9 | IL6R | 2.2 |
| PLCG2 | 20.7 | SH3GL2 | 16.8 | MAP2K7 | 2.2 |
| SPP1 | 19.7 | MAP3K5 | 16.7 | GNB2L1 | 2.1 |
| NPY1R | 18.8 | GFRA1 | 15.7 | CDK5R1 | 2.1 |
| RPS6KA5 | 10.4 | GDNF | 15.4 | PIK3R3 | 2.1 |
| CNR1 | 9.4 | KSR1 | 14.7 | HSPB1 | 2.0 |
| TGFA | 7.1 | GRPR | 14.0 | RPS6 | 2.0 |
| NCF2 | 5.5 | TGFB1 | 12.6 | EGR2 | 2.0 |
| IRAK2 | 5.5 | GMFG | 11.7 | ||
| TRO | 5.2 | UCN | 11.6 | ||
| IRS2 | 5.1 | IRAK3 | 11.1 | ||
| DOK5 | 4.9 | RAB3A | 8.0 | ||
| MAPK10 | 4.3 | NPFFR2 | 6.8 | ||
| NCK2 | 4.2 | PIK3CG | 5.8 | ||
| FYN | 3.7 | ARHGDIB | 5.0 | ||
| DNM2 | 3.3 | CBLN1 | 5.0 | ||
| RIT1 | 3.0 | IL10RA | 4.9 | ||
| NFKBIE | 2.9 | SH2B3 | 4.4 | ||
| MT3 | 2.9 | LIFR | 4.3 | ||
| SHC4 | 2.7 | NELL1 | 3.8 | ||
| DPYSL2 | 2.7 | EEF2 | 3.7 | ||
| GABRB3 | 2.6 | CX3CR1 | 3.6 | ||
| FGF9 | 2.5 | LINGO1 | 3.2 | ||
| DOCK3 | 2.3 | PTGER2 | 3.2 | ||
| ITPR3 | 2.3 | RPS6KA6 | 3.1 | ||
| PIK3R1 | 2.2 | FGFR1 | 3.1 | ||
| SIRPA | 2.2 | STAT5A | 2.9 | ||
| GAB1 | 2.2 | KRAS | 2.8 | ||
| PIK3CD | 2.2 | CRTC1 | 2.8 | ||
| CALM2 | 2.1 | MAPT | 2.7 | ||
| HRAS | 2.1 | FGF2 | 2.6 | ||
| NGFRAP1 | 2.1 | ATF4 | 2.6 | ||
| NCK1 | 2.1 | ELMO1 | 2.5 | ||
| PRKCZ | 2.1 | AP2A1 | 2.5 | ||
| DYNLT1 | 2.1 | MAPK11 | 2.5 | ||
| DNAL4 | 2.1 | JAK2 | 2.4 | ||
| MAP3K1 | 2.0 | STAT5B | 2.4 | ||
| AKT3 | 2.0 | MAP2K2 | 2.3 | ||
Transcriptome data from paired NGN3+/CD133+ and NGN3/CD133-depleted cell populations isolated from 3 biological replicate exocrine cultures. Data was analyzed for expression of 320 genes annotated as being involved with, or downstream of, neurotrophin signaling (full gene list in Additional file 8: Table S8). Gene symbol, name and fold expression in NGN3+/CD133+ cells are shown ranked by fold expression compared to NGN3/CD133-depleted cells. Genes discussed shown in bold. Only genes with a ≥2-fold difference are shown