Figure 1.

MS model. The model is based on a conventional model (Marcucci et al., 2016) with the inclusion of the mechanosensing mechanism in the rate constants between the two non-force generating states. The conventional model differs only for the absence of the mechanosensing mechanism and the inclusion of the classic actin-based cooperativity (see Materials and Methods and Supplemental Information). Rates for the attachment to and detachment from strongly attached states are functions of the strain in the i−th motor (x_i), following the original dependence hypothesized by Huxley (1957). The power stroke has two steps as reported in the left top panel. Actomyosin energy is biased by $8K\overline{T}$ every step. Left bottom figure represents the actomyosin energy plus the elastic component due to the myosin stiffness. x₀ is the extension at the time of attachment, zero in figure.