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. 2016 Sep 22;16:124. doi: 10.1186/s12911-016-0360-x

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Coagulation cascade. A simplified diagram of the coagulation cascade chemical network, showing both paths of initiation leading to the conversion of prothrombin to thrombin (IIa)