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. 2016 Aug 16;5(10):1006–1014. doi: 10.1016/j.molmet.2016.08.005

Figure 4.

Figure 4

Effect of RYGB on food intake, feed efficiency and food choice in wildtype (WT) and FGF21−/−(KO) mice. All mice were on a two choice diet consisting of high-fat and regular (low-fat) chow. A: Daily total food intake before and for 12 weeks after surgery for WT (open symbols) and FGF21−/− mice (closed symbols) after RYGB (circles), sham surgery (squares), or weight-matching (triangles, see panel b for significant differences). B: Mean daily total food intake during 4 different periods before and after surgery. C: Feed efficiency calculated on the basis of body weight gained per kcal food ingested during the period from 15 to 76 days after surgery. D, E: Preference ratio for chow over high-fat diet before and after surgery (D) and mean preference ratio for post-surgical weeks 7–8 (E). *p < 0.05 RYGB/WT vs both Sham/WT and RYGB/KO. Means ± SEM, n = 4–12 mice. Bars that do not share the same letters are significantly different from each other (p < 0.05, based on ANOVA, followed by Bonferroni-corrected multiple comparison tests).