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. 2016 Aug 5;5(10):807–822. doi: 10.1016/j.molmet.2016.07.009

Figure 3.

Figure 3

Glucose increases levels of plasma α-MSH, but not ACTH, in humans, monkeys, and mice. A. α-MSH levels and ACTH levels during an OGTT in normal body weight (control) and obese children (n = 6). B. α-MSH levels during an ivGTT in control and obese S-HFD Japanese macaques (n = 5). C. α-MSH levels during an ip GTT in control and DIO mice (n = 6). D. α-MSH levels after ip GTT/saline administration in lean mice (n = 6). E. α-MSH levels during an ip GTT in POMC-Kir6.2 mutant mice and its littermate (n = 10). Results are mean ± SEM. *p < 0.05 and **p < 0.01 by two-way ANOVA. In figures A–C, * represents the significance at time 15 or 20–40 min vs. basal values (time 0). See also Figures S2 and S3.