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. 2016 Aug 26;5(10):948–958. doi: 10.1016/j.molmet.2016.08.013

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© 2016 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Identification of Hoxc10 as a novel repressor for browning. (A) Hoxc10 expression in 3 adipose tissues from C57BL/6 mice, **: p < 0.01 vs. iWAT (n = 8, 8, 8). (B) Overexpression of HOXC10 in C3H/10T1/2 cells. Doxycycline was added on D7 of differentiation for two days. Arrow indicates the Myc-tagged HOXC10. (C) Oil Red O staining of differentiated C3H/10T1/2 adipocyte after two days' doxycycline treatment (D7-D9). (D) qPCR analysis of gene expression in fully differentiated C3H/10T1/2 cells after induction of HOXC10 expression for two days. *: p < 0.05, **: p < 0.01 for -Dox vs. +Dox (n = 3–4).