Table 2.
Association between MRS1/MRS2 (continuous score or categorized score) with incidence of type 2 diabetes measured with hazard and odds ratios; and with age at diagnosis.
| Training population (D.E.S.I.R. participants) |
Validation population |
|||||
|---|---|---|---|---|---|---|
| Hazard Ratio (p-value) |
Odds Ratio (p-value) |
Regression coefficient for association with at diagnosis (p-value) |
Hazard Ratio (p-value) |
Odds Ratio (p-value) |
Regression coefficient for association with at diagnosis (p-value) |
|
| Continuous MRS1 (unit: per standard deviation of MRS1) |
2.88 (2 × 10−16) | 8.44 (6 × 10−47) |
0.08 year (0.91) |
1.49 (8 × 10−4) |
3.3 (5 × 10−5) |
1 year (0.57) |
| Categorized MRS1 | ||||||
| 1st tertile groups vs 2nd tertile group 1st tertile groups vs 3rd tertile group |
4.13 (6 × 10−4) 21.5 (2 × 10−15) |
1.78 (2 × 10−5) 4.02 (3 × 10−24) |
7.16 years (0.06) 5.43 years (0.14) |
1.52 (0.30) 3.39 (3 × 10−3) |
1.95 (0.17) 8.46 (2 × 10−4) |
4.08 years (0.38) 0.80 year (0.86) |
| Continuous MRS2 (unit: per standard deviation of MRS2) |
2.72 (2 × 10−16) |
3.63 (6 × 10−43) |
−2.7 years (2 × 10−7) |
1.63 (1 × 10−7) |
1.78 (9 × 10−4) |
−3.75 years (4 × 10−3) |
| Categorized MRS2 | ||||||
| 1st tertile groups vs 2nd tertile group 1st tertile groups vs 3rd tertile group |
3.35 (6 × 10−4) 15.2 (2 × 10−15) |
3.04 (2 × 10−4) 18.0 (1 × 10−26) |
−1.12 years (0.67) −6.06 years (0.01) |
1.97 (0.06) 5.85 (2 × 10−6) |
2.01 (0.13) 4.71 (1 × 10−3) |
−0.81 year (0.83) −10.9 years (5 × 10−3) |