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. 2016 Oct;44(10):1709–1719. doi: 10.1124/dmd.116.072363

Fig. 5.

Fig. 5.

Metabolism of R- and S-bupropion in human liver S9 fractions. (A) R-bupropion concentration-dependent formation of R,R-OH-bupropion, S,R-erythrohydrobupropion, R,R-threohydrobupropion, and 4′-OH-bupropion in human liver S9 fractions. (B) S-bupropion concentration-dependent formation of S,S-OH-bupropion, R,S-erythrohydrobupropion, S,S-threohydrobupropion, and 4′-OH-bupropion in human liver S9 fractions. For erythrohydrobupropion formation, two of the lowest substrate concentrations are not shown, as the metabolite formation was not quantifiable in those concentrations.