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Inhibition of bupropion metabolism in human liver microsomes by ticlopidine. Ticlopidine IC50 values toward erythrohydrobupropion (A), threohydrobupropion (B), OH-bupropion (C), and 4′-OH-bupropion (D) formation were characterized following a 30-minute preincubation of HLMs with ticlopidine in the presence (filled circles) and absence (filled squares) of NADPH. Significant NADPH-dependent shifts were observed in the IC50 values for each metabolite formation.
