TABLE 2.
Transporter | Meana | Mean Percent Differenceb | CV Percent | CV Percent Differenceb | Geometric Meana | No. of Samples | No. of Studies | Heterogeneity |
References | |
---|---|---|---|---|---|---|---|---|---|---|
P | Class | |||||||||
OATP1B1 (SLCO1B1) | 3.83 | 20 | 66 | −29 | 3.2 | 64 | 3 | 0.000442 | High | Kimoto et al. (2012), Prasad et al. (2014), Peng et al. (2015) |
OATP1B3 (SLCO1B3) | 4.13 | 51 | 70 | −41 | 3.39 | 100 | 3 | 0.0225 | Moderate | Kimoto et al. (2012), Prasad et al. (2014), Peng et al. (2015) |
OATP2B1 (SLCO2B1) | 1.2 | 26 | 40 | −32 | 1.12 | 100 | 3 | 0.271 | Low | Kimoto et al. (2012), Prasad et al. (2014), Peng et al. (2015) |
OCT1 (SLC22A1) | 1.53 | 10.9 | 43 | −16 | 1.41 | 55 | 1 | N/A | N/A | Wang et al. (2015) |
NTCP (SLC10A1) | 0.757 | −19 | 41 | −39 | 0.7 | 55 | 1 | N/A | N/A | Wang et al. (2015) |
MATE1 (SLC47A1) | 0.165 | −16 | 31 | −50 | 0.158 | 55 | 1 | N/A | N/A | Wang et al. (2015) |
P-gp/MDR1 (ABCB1) | 0.201 | 0.50 | 46 | −29 | 0.183 | 109 | 3 | 0.252 | Low | Tucker et al. (2012), Prasad et al. (2014), Peng et al. (2015) |
BSEP (ABCB11) | 0.839 | 2.9 | 42 | −8 | 0.774 | 69 | 2 | 0.345 | Low | Li et al. (2009a) |
MRP2 (ABCC2) | 0.296 | −35 | 65 | 28 | 0.249 | 37 | 3 | 0.509 | Low | Wang et al. (2015) |
MRP3 (ABCC3) | 0.176 | 2.9 | 29 | −8 | 0.168 | 55 | 1 | N/A | N/A | Li et al. (2009b), Deo et al. (2012), Tucker et al. (2012) |
BCRP (ABCG2) | 0.0442 | −24 | 40 | −48 | 0.041 | 38 | 3 | 0.116 | Low | Wang et al. (2015) |
BSEP, bile salt efflux pump; MATE, multidrug and toxin extrusion protein; MDR, multidrug resistance gene; N/A, not applicable; NTCP, sodium taurocholate cotransporting polypeptide; OCT, organic cation transporter.
Values are given as picomoles per 106 hepatocytes.
Percent difference compared with the corresponding value in the complete database without exclusion criteria applied.