TABLE 2.

Weighted mean, CV, and geometric mean of total membrane protein abundance of hepatic drug transporters obtained from meta-analysis of measurements in liver tissue of healthy Caucasian adults

Transporter	Meana	Mean Percent Differenceb	CV Percent	CV Percent Differenceb	Geometric Meana	No. of Samples	No. of Studies	Heterogeneity		References
								P	Class
OATP1B1 (SLCO1B1)	3.83	20	66	−29	3.2	64	3	0.000442	High	Kimoto et al. (2012), Prasad et al. (2014), Peng et al. (2015)
OATP1B3 (SLCO1B3)	4.13	51	70	−41	3.39	100	3	0.0225	Moderate	Kimoto et al. (2012), Prasad et al. (2014), Peng et al. (2015)
OATP2B1 (SLCO2B1)	1.2	26	40	−32	1.12	100	3	0.271	Low	Kimoto et al. (2012), Prasad et al. (2014), Peng et al. (2015)
OCT1 (SLC22A1)	1.53	10.9	43	−16	1.41	55	1	N/A	N/A	Wang et al. (2015)
NTCP (SLC10A1)	0.757	−19	41	−39	0.7	55	1	N/A	N/A	Wang et al. (2015)
MATE1 (SLC47A1)	0.165	−16	31	−50	0.158	55	1	N/A	N/A	Wang et al. (2015)
P-gp/MDR1 (ABCB1)	0.201	0.50	46	−29	0.183	109	3	0.252	Low	Tucker et al. (2012), Prasad et al. (2014), Peng et al. (2015)
BSEP (ABCB11)	0.839	2.9	42	−8	0.774	69	2	0.345	Low	Li et al. (2009a)
MRP2 (ABCC2)	0.296	−35	65	28	0.249	37	3	0.509	Low	Wang et al. (2015)
MRP3 (ABCC3)	0.176	2.9	29	−8	0.168	55	1	N/A	N/A	Li et al. (2009b), Deo et al. (2012), Tucker et al. (2012)
BCRP (ABCG2)	0.0442	−24	40	−48	0.041	38	3	0.116	Low	Wang et al. (2015)

BSEP, bile salt efflux pump; MATE, multidrug and toxin extrusion protein; MDR, multidrug resistance gene; N/A, not applicable; NTCP, sodium taurocholate cotransporting polypeptide; OCT, organic cation transporter.

^aValues are given as picomoles per 10⁶ hepatocytes.

^bPercent difference compared with the corresponding value in the complete database without exclusion criteria applied.