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Inhibition of MLCK and JNK1/2 attenuate TNFα/IFNγ-induced barrier dysfunction. Caco-2 monolayers grown for 14 days postconfluence were pretreated with ML-7 (to inhibit MLCK; 1 μM) or SP600125 (SP; to inhibit JNK1/2 signaling; 1 μM) for 1 hour prior to exposure to TNFα (10 ng/ml) and IFNγ (20 ng/ml) for 16 hours. **P < 0.01 compared with control (NoRx); ***P < 0.005 compared with TNF/IFN (n = 4). A.F.U., XXX.
