Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Activation of the PXR attenuates intestinal permeability induced by TLR4 activation in WT mice (A), but not Pxr−/− mice (B). Male WT and Pxr−/− mice were pretreated with the rodent-specific PXR agonist PCN (25 mg/kg, i.p.), then administered the selective TLR4 agonist KDO2 (200 μg per mouse). After 24 hours, intestinal permeability was assessed by FITC-dextran flux assay. *P < 0.05 compared with control and PCN-treated mice; #P < 0.05 compared with KDO2 group (n = 5–6 per group).
