Fig. 6.

Competition binding profiles for ketamine’s enantiomers and metabolites against the DATs (A), NETs (B), and SERTs (C). Binding displacement by (S)-ketamine, (R)-ketamine, (S)-norketamine, (R)-norketamine, (S)-DHNK, (R)-DHNK, (2S,6S)-HNK, (2R,6R)-HNK, (2R,6S)-HNK, and (2S,6R)-HNK was determined at DAT using ³H-Win35428 [β-Carbomethoxy-3-β-(4-fluorophenyl)tropane)] with GBR12909 (-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride) as a reference ligand, at NET using ³H-nisoxetine with desipramine as a reference ligand, and at SERT using ³H-citalopram with amitriptyline as a reference ligand. Data are the mean ± S.E.M. (n ≥ 9; three or more independent experiments and three to four replicates per experiment). KET, ketamine.