TABLE 2.
Tissue specificity of TCE and PCE metabolites
| Target Tissue | Oxidative Pathway |
GSH Conjugation Pathway |
||
|---|---|---|---|---|
| TCE | PCE | TCE | PCE | |
| Liver: local formation | CH/CHL | DCVG | TCVG | |
| TCA | TCA | DCVC | TCVC | |
| TCOH | NAcDCVC | NAcTCVC | ||
| TCOG | ||||
| DCAC | TCAC | |||
| DCA | ||||
| Kidney: local formation | — | — | DCVG | TCVG |
| DCVC | TCVC | |||
| NAcDCVC | NAcTCVC | |||
| Reactive metabolites | Reactive metabolites | |||
| DCA | ||||
| Lung: local formation | CH/CHL | — | — | |
| TCA | TCA | |||
| TCOH | ||||
| DCAC | TCAC | |||
| DCA | ||||
| Testes: local formation | CH/CHL | — | — | |
| TCA | TCA | |||
| TCOH | ||||
| DCAC | TCAC | |||
| DCA | ||||
| Systemically available | CH/CHL | DCVG | TCVC | |
| TCA | TCA | DCVC | TCVC | |
| TCOH | NAcDCVC | NAcTCVC | ||
| TCOG | DCA | |||
| DCA | ||||
TCOG, trichloroethanol O-glucuronide.