TABLE 1.
Discriminative stimulus effects of saline and test drugs administered alone
| Drug |
Emax (% DAR) |
ED50 (mg/kg) |
Slope |
|||
|---|---|---|---|---|---|---|
| Mean | (S.E.M.) | Mean | (95% CI) | Mean | (S.E.M.) | |
| Cocainea | 100 | (0.0) | 4.9 | (4.2–5.9) | 1.7 | (0.08) |
| Saline | 1.8 | (1.5)* | n.a. | n.a. | n.a. | n.a. |
| Caffeinea | 77.5 | (6.3)* | 14.4 | (9.5–21.9) | 1.2 | (0.12) |
| MDPV | 98.3 | (1.1) | 0.39 | (0.25–0.58) | 2.1 | (0.33) |
| Methamphetamine | 99.8 | (0.2) | 0.37 | (0.34–0.41) | 2.3 | (0.32) |
| Midazolam | 7.6 | (5.0)* | n.a. | n.a. | n.a. | n.a. |
n.a., not applicable.
a
Emax, ED50, and slope parameters were derived from two sets of dose-response curves determined in triplicate (i.e., six dose-response curves).
*
Significant difference from cocaine as determined by one-way analysis of variance with repeated measures and post-hoc Dunnett’s test for multiple comparisons.