Table 4.
Luminal A and TNBC cell lines are driven by different endogenous metabolic networks.
| Pathway Enrichment by Metabolic Networks | Luminal A | TNBC | ||
|---|---|---|---|---|
| p-value | FDR | p-value | FDR | |
| Aminoacid metabolism_Alanine,Glycine,Cysteine metabolism and transport | 6.24E-03 | 2.26E-02 | 1.23E-06 | 1.38E-05 |
| Lipid metabolism_Phospholipid metabolism | 5.94E-05 | 1.72E-03 | ||
| 1-acyl-glycerol_3-phosphocholine pathway | 2.42E-03 | 1.75E-02 | ||
| 1-oleoyl-sn-glycero-3-phosphocholine pathway | 4.99E-03 | 2.26E-02 | ||
| 1-icosatrienoyl-sn-glycero-3-phosphocholine pathway | 5.23E-03 | 2.26E-02 | ||
| 1-docosahexaenoyl-glycerol_3-phosphocholine pathway | 5.98E-03 | 2.26E-02 | ||
| 2-arachidonoyl-glycerol_3-phosphocholine pathway | 7.67E-03 | 2.47E-02 | ||
| Glutamic acid pathways and transport | 1.74E-11 | 9.76E-10 | ||
| Aminoacid metabolism_Ala,Ser,Cys,Met,His,Pro,Gly,Glu,Gln metabolism and transport | 1.62E-09 | 3.02E-08 | ||
| Lipid metabolism_Glycosphingolipid metabolism | 1.62E-09 | 3.02E-08 | ||
| L-glutamate pathways and transport | 1.46E-07 | 2.04E-06 | ||
| Glutamic acid pathway | 1.30E-05 | 1.04E-04 | ||
| (L)-valine pathways and transport | 7.88E-04 | 3.15E-03 | ||
| Methionine pathways and transport | 1.05E-02 | 2.80E-02 | ||
| Carbohydrate metabolism_Galactose metabolism and transport | 2.58E-02 | 5.55E-02 | ||
GeneGo endogenous metabolic network analysis identified several significant biological pathways that vary between hormone receptor-positive (Luminal A) and triple-negative (TNBC) cell types based on group-differentiating metabolites. For the analysis the threshold was set to 0 with a p-value ≤ 0.05 filtering criteria, and only pathways with a p-value ≤ 0.05 and FDR ≤ 0.05 are reported. Highlighted rows distinguish pathways that are unique between the cell types defined as Luminal A versus lines defined as TNBC. FDR – False Discovery Rate.