Patients with prostate cancer and 638,218 controls with 0, 1, or 2 or more FDRs diagnosed with prostate or breast cancer

	No. FDR
Pt No.	Prostate Ca, Less Than 60	Prostate Ca, 60 or Greater	Breast Ca	No. Cases (%)		No. Controls (%)		LR (99.8% CI)*
1				43,006	(78.0)	537,996	(84.3)	0.93	(0.92,0.93)
2			1	3,509	(6.4)	45,219	(7.1)	0.90	(0.85,0.95)
3			2 or More	221	(0.4)	2,556	(0.4)	1.00	(0.81,1.24)
4		1		5,597	(10.1)	39,775	(6.2)	1.63	(1.56,1.70)
5		1	1	756	(1.4)	4,632	(0.7)	1.89	(1.67,2.13)
6		1	2 or More	52	(0.09)	378	(0.06)	1.59	(1.01,2.51)
7		2 or More		662	(1.2)	2,215	(0.3)	3.46	(3.02,3.96)
8		2 or More	1	99	(0.2)	309	(0.05)	3.71	(2.60,5.29)
9		2 or More	2 or More	8	(0.01)	24	(0.004)	3.86	(1.09,13.61)
10	1			809	(1.5)	3,785	(0.6)	2.47	(2.20,2.79)
11	1		1	85	(0.2)	419	(0.07)	2.35	(1.63,3.39)
12	1		2 or More	5	(0.009)	33	(0.005)	1.75	(0.40,7.72)
13	1	1		193	(0.3)	612	(0.1)	3.65	(2.83,4.71)
14	1	1	1	39	(0.07)	65	(0.01)	6.94	(3.71,12.98)
15	1	1	2 or More	2	(0.004)	7	(0.001)	3.31	(0.28,39.37)
16	1	2 or More		48	(0.09)	79	(0.01)	7.03	(3.99,12.37)
17	1	2 or More	1 or More	3	(0.005)	15	(0.002)	2.31	(0.33,16.33)
18	2 or More			27	(0.05)	55	(0.009)	5.68	(2.75,11.74)
19	2 or More		1 or More	4	(0.007)	6	(0.0009)	7.71	(1.05,56.68)
20	2 or More	1		18	(0.03)	21	(0.003)	9.92	(3.68,26.75)
21	2 or More	1	1 or More	3	(0.005)	3	(0.0005)	11.57	(0.93,144.21)
22	2 or More	2 or More		11	(0.02)	6	(0.0009)	21.21	(4.42,101.76)
23	2 or More	2 or More	1 or More	11	(0.02)	8	(0.001)	15.91	(3.79,66.85)

^*Percent cancer/percent controls with 99.8% CI reported to account for simultaneous significance of 23 tests at overall 95% confidence.