Table 1.
Clinical data of the study group
| Subgroup | Cases (n = 872)
|
Controls (n = 1,482)
|
|
|---|---|---|---|
| No. (%) | No. (%) | ||
| Ethnic background | |||
| Caucasian | 596 (68.4) | 840 (56.7) | |
| Hispanic | 194 (22.2) | 454 (30.6) | |
| African American | 82 (9.4) | 188 (12.7) | |
| Age, in y | |||
| 46–50 | 35 (4.0) | 199 (13.4) | |
| 51–60 | 212 (24.3) | 536 (36.1) | |
| 61–70 | 378 (43.4) | 485 (32.7) | |
| >70 | 247 (28.3) | 262 (17.8) | |
| Mean ± SD | 65.5 ± 8.5 | 61.3 ± 9.2 | P < 0.0001 |
| Family history* | 95 | 398 | |
| 1st-degree relative | 74 | 300 | |
| Brother | 37 | 79 | |
| Father | 52 | 247 | |
| 2nd-degree relative | 97 | 151 | |
| Age onset sporadic | 66.3 ± 8.4 | P < 0.0001 | |
| Age onset familial | 63.9 ± 8.4 | ||
| Disease aggressiveness (Gleason) | |||
| Total <7 | 332 | ||
| Sporadic <7 | 215 | ||
| Familial <7 | 117 | ||
| Total ≥7 | 247 | ||
| Sporadic ≥7 | 163 | ||
| Familial ≥7 | 84 | ||
| Prostate specific antigen (ng/mL) | |||
| ≤4.0 | 180 | 1482 | |
| 4.1–10.0 | 36 | 0 | |
| 10.1–20.0 | 3 | 0 | |
| >20.0 | 4 | 0 | |
| Mean ± SD | 3.16 ± 4.72 | 0.86 ± 0.44 | P < 0.0001 |
*
Family history data are from the SABOR cohort only.