Table 2.
Gene | SNP | Position | Function SNP | Minor Allele | Caucasians
|
Hispanics
|
African Americans
|
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAF case | MAF control | P* | MAF case | MAF control | P* | MAF case | MAF control | P* | |||||
RNASEL | rs17568993 | chr1:180804117 | A | 0.126 | 0.135 | 0.503 | 0.08 | 0.061 | 0.226 | 0.073 | 0.117 | 0.129 | |
rs12757998 | chr1:180805101 | A | 0.284 | 0.309 | 0.149 | 0.198 | 0.198 | 0.999 | 0.177 | 0.139 | 0.270 | ||
rs635261 | chr1:180805664 | C | 0.383 | 0.37 | 0.484 | 0.402 | 0.406 | 0.901 | 0.287 | 0.262 | 0.569 | ||
rs10911099 | chr1:180806772 | G | 0.115 | 0.116 | 0.934 | 0.085 | 0.062 | 0.154 | 0.049 | 0.028 | 0.232 | ||
rs1048260 | chr1:180809474 | 3′UTR | G | 0.296 | 0.287 | 0.628 | 0.304 | 0.295 | 0.752 | 0.213 | 0.194 | 0.621 | |
rs11072 | chr1:180809954 | 3′UTR | G | 0.302 | 0.297 | 0.768 | 0.31 | 0.304 | 0.827 | 0.216 | 0.201 | 0.692 | |
rs1048254 | chr1:180810289 | 3′UTR | C | 0.298 | 0.293 | 0.756 | 0.265 | 0.266 | 0.987 | 0.213 | 0.207 | 0.865 | |
rs533259 | chr1:180815642 | A | 0.069 | 0.064 | 0.619 | 0.028 | 0.043 | 0.211 | 0.213 | 0.238 | 0.548 | ||
rs627928 | chr1:180817960 | Glu541Asp | G | 0.543 | 0.553 | 0.678 | 0.513 | 0.467 | 0.244 | 0.329 | 0.314 | 0.767 | |
rs516134 | chr1:180820316 | G | 0.03 | 0.032 | 0.703 | 0.008 | 0.018 | 0.174 | 0.152 | 0.198 | 0.223 | ||
rs486907 | chr1:180821180 | Gln462Arg | A | 0.351 | 0.337 | 0.528 | 0.313 | 0.244 | 0.052 | 0.236 | 0.119 | 0.004 | |
rs3738579 | chr1:180822659 | 5′UTR | G | 0.343 | 0.338 | 0.759 | 0.265 | 0.216 | 0.061 | 0.134 | 0.133 | 0.965 | |
rs682585 | chr1:180826133 | A | 0.382 | 0.39 | 0.673 | 0.446 | 0.486 | 0.196 | 0.146 | 0.108 | 0.220 | ||
MSR1 | rs918 | chr8:16011449 | 3′UTR | A | 0.055 | 0.057 | 0.792 | 0.098 | 0.107 | 0.637 | 0.189 | 0.148 | 0.247 |
rs1904577 | chr8:16016055 | G | 0.126 | 0.128 | 0.843 | 0.273 | 0.302 | 0.315 | 0.396 | 0.444 | 0.310 | ||
rs11780669 | chr8:16018641 | G | 0.083 | 0.095 | 0.247 | 0.039 | 0.028 | 0.325 | 0.012 | 0.028 | 0.273 | ||
rs12114368 | chr8:16025334 | A | 0.035 | 0.036 | 0.832 | 0.169 | 0.208 | 0.117 | 0.08 | 0.071 | 0.713 | ||
rs12681382 | chr8:16029033 | G | 0.029 | 0.031 | 0.714 | 0.102 | 0.129 | 0.178 | 0.018 | 0.019 | 0.986 | ||
rs2127565 | chr8:16030930 | G | 0.119 | 0.131 | 0.355 | 0.29 | 0.312 | 0.445 | 0.644 | 0.614 | 0.528 | ||
rs4333601 | chr8:16042345 | 3′UTR | C | 0.234 | 0.239 | 0.745 | 0.418 | 0.443 | 0.412 | 0.433 | 0.54 | 0.025 | |
rs12718376 | chr8:16042516 | 3′UTR | A | 0.107 | 0.153 | 0.002 | 0.301 | 0.235 | 0.092 | 0.46 | 0.524 | 0.430 | |
rs17484273 | chr8:16044606 | A | 0.315 | 0.335 | 0.255 | 0.284 | 0.299 | 0.584 | 0.207 | 0.207 | 0.989 | ||
rs17484315 | chr8:16055103 | C | 0.043 | 0.047 | 0.606 | 0.008 | 0.009 | 0.843 | 0.012 | 0 | 0.046 | ||
rs3747531 | chr8:16057019 | Ala275Pro | G | 0.047 | 0.058 | 0.216 | 0.142 | 0.179 | 0.104 | 0.073 | 0.075 | 0.957 | |
rs351572 | chr8:16065839 | G | 0.438 | 0.404 | 0.067 | 0.265 | 0.239 | 0.327 | 0.341 | 0.256 | 0.049 | ||
rs754331 | chr8:16067989 | A | 0.465 | 0.484 | 0.310 | 0.363 | 0.361 | 0.926 | 0.256 | 0.247 | 0.825 | ||
rs13251251 | chr8:16073863 | A | 0.064 | 0.06 | 0.655 | 0.031 | 0.031 | 0.977 | 0 | 0.006 | 0.313 | ||
rs614794 | chr8:16085228 | G | 0.12 | 0.119 | 0.894 | 0.365 | 0.398 | 0.277 | 0.366 | 0.358 | 0.865† | ||
rs3789015 | chr8:16087084 | G | 0.039 | 0.045 | 0.461 | 0.137 | 0.177 | 0.079 | 0.079 | 0.08 | 0.970 | ||
rs6530946 | chr8:16099299 | G | 0.14 | 0.158 | 0.335 | 0.392 | 0.442 | 0.132 | 0.594 | 0 | 0 | ||
ELAC2 | rs2072262 | chr17:12833668 | G | 0.129 | 0.116 | 0.315 | 0.104 | 0.111 | 0.694 | 0.134 | 0.167 | 0.349 | |
rs2072261 | chr17:12833814 | A | 0.237 | 0.239 | 0.871 | 0.227 | 0.25 | 0.381 | 0.119 | 0.108 | 0.724 | ||
rs2523 | chr17:12836540 | 3′UTR | G | 0.349 | 0.345 | 0.805 | 0.381 | 0.402 | 0.497 | 0.476 | 0.515 | 0.406 | |
rs1044564 | chr17:12836709 | 3′UTR | G | 0.35 | 0.348 | 0.917 | 0.381 | 0.401 | 0.514 | 0.481 | 0.534 | 0.275 | |
rs17552022 | chr17:12839020 | Thr631Thr | G | 0.122 | 0.091 | 0.018 | 0.077 | 0.059 | 0.291 | 0.013 | 0.01 | 0.826 | |
rs11545302 | chr17:12840688 | Thr520Thr | G | 0.268 | 0.189 | 9.1 × 10−6 | 0.259 | 0.263 | 0.888 | 0.2 | 0.068 | 2.0 × 10−4 | |
rs11658321 | chr17:12855209 | A | 0.35 | 0.341 | 0.604 | 0.41 | 0.408 | 0.957 | 0.665 | 0.698 | 0.459 | ||
rs2051974 | chr17:12862370 | A | 0.233 | 0.242 | 0.601 | 0.22 | 0.198 | 0.382 | 0.427 | 0.466 | 0.411 | ||
rs8077923 | chr17:12864712 | C | 0.14 | 0.158 | 0.194 | 0.179 | 0.18 | 0.964 | 0.201 | 0.176 | 0.496 | ||
rs7218504 | chr17:12868379 | C | 0.309 | 0.315 | 0.737 | 0.302 | 0.27 | 0.253 | 0.39 | 0.41 | 0.676 | ||
rs12943765 | chr17:12868955 | G | 0.059 | 0.048 | 0.201 | 0.062 | 0.039 | 0.087 | 0.055 | 0.049 | 0.795 |
NOTE: Significant P values are in bold.
Assumes Hardy-Weinberg equilibrium.
SNP not in Hardy-Weinberg equilibrium (P < 0.01).