Table 3.

Significant results from individual SNP effects on prostate cancer in Caucasians, Hispanics, and African Americans after correction for multiple testing

Gene	SNP	Genotype	Controls (n)	Cases (n)	OR* (95% CI)	P
Caucasians
MSR1	rs12718376	GG	484	329	1.00
		AA	18	5	0.32 (0.12–0.90)	0.031
		AG	170	78	0.68 (0.50–0.92)	0.014
		AA/AG vs GG	188	83	0.64 (0.48–0.86)	0.004
MSR1	rs17484273	GG	371	263	1.00
		AA	95	44	0.66 (0.45–0.98)	0.041
		AG	372	285	1.06 (0.85–1.33)	0.590
		AA vs AG/GG	95	44	0.64 (0.44–0.94)	0.022
MSR1	rs351572	AA	306	175	1.00
		GG	145	102	1.26 (0.91–1.73)	0.159
		AG	388	315	1.40 (1.10–1.78)	0.007
		GG/AG vs AA	533	417	1.36 (1.08–1.71)	0.009
ELAC2	rs17552022	AA	443	427	1.00
		GG	5	9	1.92 (0.63–5.83)	0.251
		AG	87	117	1.38 (1.01–1.88)	0.043
		GG/AG vs AA	92	126	1.41 (1.04–1.91)	0.027
ELAC2	rs11545302†	AA	356	311	1.00
		GG	21	41	2.19 (1.25–3.82)	0.006
		AG	161	229	1.67 (1.29–2.16)	1.0 × 10−4
		GG/AG vs AA	182	270	1.73 (1.36–2.22)	1.0 × 10−5
Hispanics
RNASEL	rs627928	TT	59	41	1.00
		GG	48	45	1.49 (0.83–2.69)	0.186
		GT	120	70	0.80 (0.48–1.33)	0.390
		GG vs GT/TT	48	45	1.72 (1.05–2.81)	0.030
RNASEL	rs486907	GG	126	75	1.00
		AA	7	17	4.18 (1.61–10.85)	0.003
		AG	91	64	1.16 (0.75–1.81)	0.508
		AA vs AG/GG	7	17	3.92 (1.54–9.96)	0.004
RNASEL	rs682585	GG	96	64	1.00
		AA	85	43	0.72 (0.43–1.20)	0.207
		AG	210	87	0.52 (0.34–0.80)	0.003
		AA/AG vs GG	295	130	0.58 0.38–0.86	0.007
MSR1	rs12114368	GG	246	139	1.00
		AA	20	12	0.97 (0.44–2.14)	0.940
		AG	121	41	0.58 (0.38–0.90)	0.015
		AA/AG vs GG	141	53	0.64 (0.43–0.95)	0.029
African Americans
MSR1	rs4333601	CC	46	14	1.00
		AA	33	25	2.57 (1.13–5.83)	0.024
		AC	83	43	1.74 (0.84–3.58)	0.134
		A # vs C #	162	82	1.59 (1.06–2.39)	0.024
MSR1	rs351572	AA	89	33	1.00
		GG	10	7	2.32 (0.78–6.84)	0.128
		AG	63	42	1.84 (1.03–3.28)	0.039
		GG/AG vs AA	73	49	1.90 (1.09–3.32)	0.025

NOTE: Significant P values are in bold.

^*Age adjusted.

^†Main effect independent from other significant SNPs.