Table 4.
Risk estimates of variants in RNASEL for cancer by interaction effects of family history (left) and family history stratification (right) in Hispanics
| SNP | Genotype | Interaction model
|
Genotype | Stratified: no family history
|
Stratified: family history
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls/Cases (n) | OR (95% CI) | P | Controls/Cases (n) | OR (95% CI) | P | Controls/Cases (n) | OR (95% CI) | P | |||
| rs12757998 | GG | 258/126 | Ref | 213/88 | Ref | 45/38 | Ref | ||||
| AG | 114/59 | 1.41 (0.88–2.25) | 0.149 | 77/47 | 1.41 (0.88–2.25) | 0.148 | 37/12 | 0.33 (0.14–0.77) | 0.011 | ||
| AA/AG vs GG | 135/68 | 1.30 (0.83–2.04) | 0.246 | 93/52 | 1.30 (0.83–2.03) | 0.246 | 42/16 | 0.41 (0.19–0.88) | 0.023 | ||
| AG*GxE | 37/12 | 0.24 (0.09–0.62) | 0.008 | ||||||||
| AA/AG vs GG *GxE | 135/68 | 0.32 (0.13–0.76) | 0.010 | ||||||||
| rs635261 | GG | 140/69 | Ref | 107/55 | Ref | 33/14 | Ref | ||||
| CC | 66/31 | 0.77 (0.41–1.45) | 0.421 | 61/21 | 0.77 (0.41–1.44) | 0.416 | 5/10 | 6.22 (1.67–23.2) | 0.006 | ||
| CC vs CG/GG | 66/31 | 0.83 (0.47–1.48) | 0.534 | 61/21 | 0.83 (0.47–1.47) | 0.527 | 5/10 | 4.58 (1.40–15.0) | 0.012 | ||
| CC*GxE | 5/10 | 7.81 (1.86–32.9) | 0.016 | ||||||||
| CC vs CG/GG*GxE | 66/31 | 5.39 (1.46–19.9) | 0.009 | ||||||||
| rs1048260 | CC | 191/94 | Ref | 148/75 | Ref | 43/19 | Ref | ||||
| CG | 172/82 | 0.77 (0.49–1.20) | 0.251 | 134/54 | 0.77 (0.49–1.20) | 0.252 | 38/28 | 2.07 (0.94–4.54) | 0.069 | ||
| GG/CG vs CC | 202/100 | 0.76 (0.50–1.17) | 0.210 | 158/65 | 0.76 (0.50–1.17) | 0.212 | 44/35 | 2.18 (1.03–4.63) | 0.042 | ||
| CG*GxE | 38/28 | 2.65 (1.09–6.46) | 0.049 | ||||||||
| GG/CG vs CC *GxE | 202/100 | 2.82 (1.20–6.62) | 0.016 | ||||||||
| rs11072 | AA | 183/90 | Ref | 142/72 | Ref | 41/18 | Ref | ||||
| AG | 173/85 | 0.82 (0.53–1.29) | 0.394 | 135/56 | 0.82 (0.53–1.29) | 0.393 | 38/29 | 2.03 (0.92–4.46) | 0.078 | ||
| GG/AG vs AA | 204/102 | 0.79 (0.51–1.21) | 0.273 | 160/66 | 0.79 (0.51–1.21) | 0.275 | 44/36 | 2.13 (1.00–4.54) | 0.049 | ||
| AG*GxE | 38/29 | 2.43 (0.99–5.94) | 0.059 | ||||||||
| GG/AG vs AA *GxE | 204/102 | 2.66 (1.13–6.28) | 0.024 | ||||||||
| rs1048254 | AA | 208/103 | Ref | 159/82 | Ref | 49/21 | Ref | ||||
| AC | 161/79 | 0.80 (0.51–1.25) | 0.326 | 126/51 | 0.80 (0.51–1.25) | 0.325 | 35/28 | 1.93 (0.90–4.11) | 0.090 | ||
| CC/AC vs AA | 185/91 | 0.76 (0.50–1.17) | 0.215 | 147/58 | 0.76 (0.50–1.17) | 0.215 | 38/33 | 2.14 (1.03–4.46) | 0.042 | ||
| AC*GxE | 35/28 | 2.40 (1.00–5.76) | 0.022 | ||||||||
| CC/AC vs AA *GxE | 185/91 | 2.80 (1.20–6.52) | 0.016 | ||||||||
| rs627928* | TT | 59/41 | Ref | GG | 40/28 | Ref | 19/16 | Ref | |||
| GT | 120/69 | 1.05 (0.57–1.96) | 0.866 | GT | 90/58 | 0.83 (0.45–1.53) | 0.559 | 30/11 | 0.40 (0.15–1.08) | 0.071 | |
| GG vs GT/TT | 48/45 | 1.21 (0.68–2.15) | 0.519 | TT vs GT/GG | 40/25 | 0.90 (0.50–1.62) | 0.715 | 8/17 | 4.40 (1.63–11.9) | 0.003 | |
| GT*GxE | 30/11 | 0.37 (0.12–1.20) | 0.013 | ||||||||
| GG vs GT/TT *GxE | 48/45 | 3.85 (1.23–12.0) | 0.018 | ||||||||
NOTE: Significant P values are in bold.
Abbreviation: GxE, Interaction gene-environment.
*
SNP significant in single-SNP analysis.