2.

Levonorgestrel‐releasing IUC compared with no hormonal contraceptive for effect on weight
Patient or population: women with need for contraception Settings: clinic Intervention: LNG‐IUC Comparison: no hormonal contraceptive
Outcomes by 1 year	Relative effect (95% CI)	Participants (study)	Quality of the evidence (GRADE)	Comments
Change in fat mass (%); change in lean mass (%)	Reported mean ± SD (reported P): 2.5 ± 8.0 vs ‐1.3 ± 6.9 (P = 0.029); ‐1.4 ± 4.7 vs 1.0 ± 3.8 (P = 0.027)	76 (Dal'Ava 2012)	Moderate	LNG‐IUC vs non‐hormonal IUC; women 18 to 45 years old
Change in fat mass (%); change in fat free mass (%)	MD 1.60 (0.45 to 2.75); MD ‐1.60 (‐2.75 to ‐0.45)	60 (Napolitano 2015)	Low	LNG‐IUC vs no contraceptive; perimenopausal women
CI: Confidence interval; MD = mean difference; SD = standard deviation
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.

IUC: intrauterine contraception
 LNG‐IUC: levonorgestrel‐releasing intrauterine contraception