Comparison 3. DMPA 150 mg/mL versus COC.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Weight gain ≥ 1 kg at month 6	1	31	Odds Ratio (M‐H, Fixed, 95% CI)	0.39 [0.09, 1.67]
2 Weight gain ≥ 1 kg at month 12	1	26	Odds Ratio (M‐H, Fixed, 95% CI)	0.44 [0.08, 2.39]
3 Weight loss ≥ 1 kg at month 6	1	31	Odds Ratio (M‐H, Fixed, 95% CI)	9.24 [0.44, 195.69]
4 Weight loss ≥ 1 kg at month 12	1	26	Odds Ratio (M‐H, Fixed, 95% CI)	1.83 [0.15, 23.15]
5 Mean weight change (kg) at 6 months	1	142	Mean Difference (IV, Fixed, 95% CI)	‐0.50 [‐2.26, 1.26]
6 Mean weight change (kg) at 12 months	1	81	Mean Difference (IV, Fixed, 95% CI)	0.7 [‐1.92, 3.32]
7 Mean percentage weight change at 6 months	1	142	Mean Difference (IV, Fixed, 95% CI)	‐0.7 [‐3.10, 1.70]
8 Mean percentage weight change at 12 months	1	81	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐3.79, 3.79]