Tankeyoon 1976.

Methods	Design: prospective metabolic study; focused on metabolic effects of contraceptive methods Location: Bangkok, Thailand Time frame: no information Sample size estimation and outcome of focus: no sample size calculation; focused on metabolic effects of contraceptive methods
Participants	32 healthy women attending the family planning clinic; age 18 to 38 years Inclusion criteria: > 6 weeks postpartum and no other steroid use for past 3 months Exclusion criteria: no information
Interventions	1) DMPA 150 mg (3‐month intervals) (N = 16) 2) COC: d‐norgestrel 50 µg + EE 50 µg (N = 16)
Outcomes	Percent of cases with ≥ 1 kg increase or decrease in body weight by contraceptive method Follow‐up: 1, 2, 3, 6, 9, 12 months
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Women receiving contraceptive method; presumably chose method
NOS selection (NRS)	Low risk	Exposed: clinic population, volunteered for study Non‐exposed: same as exposed group but chose different contraceptive Exposure: presumably from clinic records
NOS comparability (NRS)	Low risk	Analysis: adjusted for pretreatment value
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not feasible due to women presumably having chosen method
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information; objective outcome measure
Incomplete outcome data (attrition bias) All outcomes	High risk	Loss to follow‐up: 19% by 12 months; DMPA 2/16 (13%) and COC 4/16 (25%) Differential losses between groups though sample sizes are small Reasons for missing data not specified