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. 2016 Aug 28;2016(8):CD008815. doi: 10.1002/14651858.CD008815.pub4
Study Reason for exclusion
Agoestina 1978 Insufficient weight change data: presented in figure without any specific numbers, other than mean gain for DMPA group in text
Bahamondes 2010 Mean weight change not reported. BMI included as control variable for examining bone mineral density.
Study examined weight change among participants who had been using the method (LNG‐IUC) for at least 7 years before the study.
Barsivala 1974 Insufficient data: study duration not reported (our criteria was ≥ 3 months); also, investigators did not specify whether the variance reported is standard deviation or standard error.
Beksinska 2010 Analysis combined users of DMPA, NET‐EN, or both. Investigators noted the subgroups were too small to analyze separately and that differences in weight gain were not significant.
Berenson 1997 Insufficient weight change data: means reported without any variance measure
Berenson 2009 Insufficient weight change data: mean change reported without any variance.
 Of 240 who chose DMPA, 60% discontinued the method by 12 months and 76% discontinued by 36 months. DMPA users with > 5% weight increase at 6‐month visit were more likely lost to follow‐up by next visit than those who had not gained such weight.
Secondary report (Rahman 2012) provided weight gain (by kg categories) over any 6‐month period; categories overlapped.
Bonny 2006 Analysis combined groups that received DMPA + placebo or DMPA + estradiol supplement; reportedly DMPA groups did not differ in weight gain.
DMPA discontinuation 37% at 18 months; data from 2000 to 2003
Bonny 2011 Not comparative
Bonny 2015 Not comparative
Casey 2013 Insufficient data: no weight change reported
Chen 2011 Abstract notes that weight gain was reported as side effect. Wrote to investigator regarding whether weight change was measured. Unable to obtain further information.
Clark 2005 Insufficient weight change data: means (not mean change) presented in a figure. Text mentions mean change for DMPA at 30 months (no variance measure) and that the control group was basically unchanged. Due to discontinuations of DMPA and initiation of hormonal contraception among controls, the samples sizes were 17% (DMPA) and 19% (controls) of baseline by the last visit.
Costa 2012 Mean change in weight was not reported. Participants were 1.5 months postpartum.
Dahlberg 1982 Insufficient weight change data: means reported without any variance measure
El Mahgoub 1980 Insufficient weight change data: mean change reported without any variance measure. Also, percent that lost or gained weight was reported, but no specific amount of weight was provided.
Gallo 2016 Two arms: immediate and delayed insertion of Sino‐Implant II. Secondary analysis of data from RCT that examined condom use. Delayed group was offered OC prescription; no information on how many used it.
Hall 1980 Insufficient weight change data: mean change in 'ideal body weight' shown in figure, except for mean change for progestin‐only group reported in text.
Havranek 1972 Insufficient weight data: mean change for one group reported without any variance measure
Hernandez‐Juarez 2014 Insufficient weight data; weight change not reported
Kaunitz 2009 Insufficient weight data. Mean change was reported within adverse event section without any variance measure. Data from 2001 to 2004.
Mangan 2002 Comparison groups were DMPA users and OC users. Types of OC were not specified and might have included progestin‐only as well as combination OC.
Modesto 2014b Insufficient data: counseling only; no weight change measured
Nault 2013 Insufficient data: weight gain not broken down by contraceptive type
Olsson 1988 Insufficient data for analysis: no N per group for analysis. First‐year continuation rate was 59% for Norplant and 77% for Norplant‐2; methods suggest these were life‐table rates.
Ortayli 2001 Insufficient data: report does not provide sample sizes used for analysis. Outcome data are from a pilot conducted in 1995 and the main study conducted from 1996 to 1998.
Risser 1999 Comparison groups were DMPA users and OC users. Types of OC were not specified and might have included progestin‐only as well as combination OC.
Segall‐Gutierrez 2012 Single‐arm study comparing normal weight and obese women. The one intervention was subcutaneous DMPA.
Veisi 2013 Insufficient weight data: self‐reported weight only
WHO 1978 Insufficient weight data: mean gains reported without any variance measure
Yela 2006 Insufficient weight change data: tables show weight and BMI means (not change) by year; text mentions mean change per group over 5 years without any variance measure. Study began in 1998.
Zheng 1999 Insufficient weight change data: means reported without any variance measure

BMI: body mass index
 DMPA: depot medroxyprogesterone acetate
 LNG‐IUC: levonorgestrel‐releasing intrauterine contraception
 NET‐EN: norethisterone enanthate
 OC: oral contraceptive