Table 2.
Cox Proportional Hazards Models for Metastasis‐Free Survival and Overall Survival
| Metastasis‐Free Survival | Overall Survival | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis | Univariate Analysis | Multivariate Analysis | |||||
| Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P | |
| Age | ||||||||
| ≤12 y | Reference | Reference | Reference | Reference | ||||
| 13‐19 y | 1.51 (1.04‐2.21) | .031 | 1.51 (1.03‐2.21) | .035 | 1.74 (1.00‐3.02) | .049 | 1.72 (0.98‐3.00) | .058 |
| 20‐39 y | 1.30 (0.85‐2.00) | .229 | 1.28 (0.82‐1.98) | .277 | 1.85 (1.01‐3.38) | .046 | 1.96 (1.06‐3.64) | .032 |
| ≥40 y | 2.55 (1.57‐4.16) | <.001 | 2.12 (1.28‐3.52) | .004 | 4.31 (2.26‐8.24) | <.001 | 3.50 (1.77‐6.92) | <.001 |
| Sex | ||||||||
| Male | Reference | Reference | Reference | Reference | ||||
| Female | 0.83 (0.62‐1.10) | .198 | 0.85 (0.64‐1.14) | .271 | 0.60 (0.40‐0.90) | .013 | 0.62 (0.41‐0.93) | .022 |
| Tumor size | ||||||||
| ≤8 cm | Reference | Reference | Reference | Reference | ||||
| >8 cm | 1.64 (1.23‐2.18) | .001 | 1.53 (1.14‐2.06) | .005 | 1.69 (1.14‐2.48) | .008 | 1.59 (1.05‐2.39) | .028 |
| Tumor site | ||||||||
| Distal extremity | Reference | Reference | Reference | Reference | ||||
| Distal femur | 1.98 (1.00‐3.92) | .05 | 1.80 (0.90‐3.58) | .095 | 9.27 (1.28‐67.10) | .028 | 8.39 (1.15‐61.06) | .036 |
| Proximal tibia/fibula | 1.74 (0.857‐3.54) | .125 | 1.72 (0.84‐3.50) | .138 | 10.21 (1.40‐74.64) | .022 | 10.75 (1.46‐78.90) | .020 |
| Proximal humerus | 3.13 (1.45‐6.73) | .004 | 2.84 (1.31‐6.14) | .008 | 10.36 (1.33‐80.95) | .026 | 9.45 (1.20‐74.15) | .033 |
| Proximal femur | 2.31 (1.02‐5.24) | .044 | 1.90 (0.83‐4.33) | .127 | 17.89 (2.34‐136.77) | .005 | 14.15 (1.84‐108.72) | .011 |
| Trunk | 2.98 (1.25‐7.06) | .013 | 2.27 (0.95‐5.43) | .065 | 19.76 (2.47‐158.07) | .005 | 13.15 (1.63‐105.93) | .015 |
| Pathologic fracture | ||||||||
| No | Reference | Reference | Reference | Reference | ||||
| Yes | 1.81 (1.15‐2.84) | .01 | 1.66 (1.05‐2.63) | .032 | 2.38 (1.40‐4.04) | .004 | 2.55 (1.46‐4.43) | .001 |
| Histologic response (tumor necrotic rate) | ||||||||
| Grade 1 (<50%) | Reference | Reference | Reference | Reference | ||||
| Grade 2 (50%‐89%) | 0.71 (0.51‐0.99) | .046 | 0.71 (0.51‐0.99) | .045 | 0.55 (0.35‐0.85) | .008 | 0.57 (0.36‐0.90) | .015 |
| Grade 3 (90%‐99%) | 0.50 (0.35‐0.71) | <.001 | 0.53 (0.37‐0.77) | .001 | 0.41 (0.25‐0.65) | <.001 | 0.48 (0.29‐0.78) | .003 |
| Grade 4 (100%) | 0.33 (0.18‐0.58) | <.001 | 0.35 (0.19‐0.62) | <.001 | 0.25 (0.11‐0.55) | .001 | 0.28 (0.12‐0.63) | .002 |
Abbreviation: CI, confidence interval.