Table 2.
Thresholds for determining the extent of an effect
| Extent category | Outcome category | ||
|---|---|---|---|
| All‐cause mortality | Serious (or severe) symptoms (or late complications) and adverse events, as well as quality of lifea ) | Nonserious (or nonsevere) symptoms (or late complications) and adverse events | |
| Major | 0.85 | 0.75 and risk ≥ 5%b ) | Not applicable |
| Considerable | 0.95 | 0.90 | 0.80 |
| Minor | 1.00 | 1.00 | 0.90 |
a
Precondition (as for all patient‐reported outcomes): use of a validated or established instrument, as well as a validated or established response criterion.
b
Risk must be at least 5% for at least one of the two groups compared.