Biological properties of all possible PIP stoichiometric tetramers. Arrows represent the expression level of PIP1/PIP2; θ, PIP tetramer stoichiometry; Ω (10−4 cm s−1 ng−1), Pf contribution of each tetrameric species at the plasma membrane; pH0.5, pH at which the Pf change is half maximal; n, Hill coefficient; and α, cellular localization of tetramers. PM corresponds to plasma membrane and IN indicates intracellular localization.