Skip to main content
. 2016 Jul 1;10(6):498–506. doi: 10.1080/19336950.2016.1207021

Figure 2.

Figure 2.

Phenamil and benzamil fails to elicit concentration-dependent effects on the hGABA-(A)ρ1 receptor. (A) Resulting representative traces generated by the co-application of GABA (10 µM) with increasing concentrations of phenamil in the presence of the wild type hGABA-A ρ1 receptor are shown. (B) Summary of phenamil activity on hGABA-A ρ1 receptor mediated peak current amplitude. Response to GABA and phenamil were normalized to the peak current amplitude of the control. (C) Resulting representative responses generated by the co-application of GABA (10 µM) with increasing concentrations of benzamil in the presence of the wild type hGABA-A ρ1 receptor are shown. (D) Summary of benzamil activity on hGABA-A ρ1 receptor mediated peak current amplitude. Responses to GABA and benzamil were normalized to the peak current amplitude of the GABA. Benzamil failed to elicit significant effects on the GABA-A ρ1 receptor. Data are presented as the mean ± SEM of n ≥ 4 cells. Dashed square highlights the guanidine group.