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HMA potentiates the hGABA-(A)ρ1 I15'N mutant receptor. (A) Representative responses to increasing concentrations of HMA co-applied with GABA (3 µM) on the hGABA-A ρ1 (I15'N) mutant receptor are shown. (B) Concentration-response profile of HMA potentiation of GABA-mediated current is shown. The resulting HMA EC50 was 16.55 ± 0.16 mM with a Hill coefficient of 1.37 ± 0.71. Data are presented as the mean ± SEM of n ≥ 4 cells.
