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. 2016 Jul 1;10(6):498–506. doi: 10.1080/19336950.2016.1207021

Figure 4.

Figure 4.

Phenamil and benzamil fail to elicit a concentration-dependent increase in GABA-induced current on the hGABA-A ρ1 (I15'N) mutant receptor. (A) Representative current traces of increasing concentrations of phenamil co-applied with 3 µM GABA on the hGABA-A ρ1 (I15'N) mutant receptor are shown. (B) Comparison of normalized response of co-application of control GABA and phenamil in the presence of the hGABA-A ρ1 I15'N mutant receptor is presented. (C) Representative current traces of increasing concentrations of benzamil co-applied with 3 µM GABA in the presence of the hGABA-A ρ1 I15'N mutant receptor are shown. (D) Comparison of normalized response of co-application of control GABA and increasing concentrations of benzamil. Data are presented as the mean ± SEM of n ≥ 4 cells. Significance was determined using One-way ANOVA and Bonferroni post-hoc analysis (****, p ≤ 0.0001 compared to the control response).