Table 3.

Medications with FDA indication for treatment of BD

	Acute episode			Maintenance
Medication	Mania	Depression	Mixed
Mood stabilizers
Lithium	M, C		X	M, C
Divalproex, divalproex ER	M, C		X	X
Carbamazepine, carbamazepine ER	M, C		M, C
Lamotrigine		X		M, C
Atypical antipsychotics
Aripiprazole	M, A		M, A	M, A
Asenapine	M, A		M, A
Lurasidone		M (BP I)
Olanzapine	M, A	C (with fluoxetine, BP I)	M, A	M*
Quetiapine IR, XR	M, A	M (BP I and II)	M, A (only XR)	A
Risperidone	M, A		M, A	M, A (only RLAI)
Ziprasidone	M*		M*	A

*Also used adjunctively but not FDA indicated.

A, adjunctive to a mood stabilizer; C, combination therapy with another mood stabilizer, antipsychotic, or antidepressant; M, monotherapy; RLAI risperidone long‐acting injectable; X, recommended in guidelines but not FDA indicated.