Table 1.

Body Weight and Hepatic Biomarker¹

Objective outcomes	Month 3		Month5		Month 7		P (2-way ANOVA)
	WD	WBD	WD	WBD	WD	WBD	Time	Diet	Time*Diet
Body weight [g]	39.5 ± 3.7b	39.9 ± 4.6b	47.0 ± 3.7a	46.0 ± 2.6a	48.9 ± 3.4a	50.5 ± 3.1a	< 0.0001	NS	NS
Liver [%]1	5.2 ± 1.3c	5.4 ± 1.1c	7.2 ± 0.9ab	6.4 ± 1.2bc	6.4 ± 1.4bc	8.5 ± 1.7a	0.0013	NS	0.0326
Hepatic TG [mg]	132 ± 37c	112 ± 51c	261 ± 60a	149 ± 65bc	231 ± 120ab	306 ± 92a	0.0006	NS	0.0296
NAFLD score	1.5 ± 0.5b	0.5 ± 0.5c	2.0 ± 0.0ab	0.5 ± 0.5c	2.5 ± 0.5a	1.5 ± 0.5b	< 0.0001	< 0.0001	NS
ALT [IU/L]	16.8 ± 3.1c	16.1 ± 3.7c	48.3 ± 9.2a	30.3 ± 6.3b	42.1 ± 9.8a	50.7 ± 14.2a	< 0.0001	NS	0.0080
QR activity [nmol MTT]2	28.9 ± 7.2e	33.3 ± 7.1de	44.0 ± 5.9bc	40.7 ± 8.7cd	52.2 ± 12.8b	65.4 ± 6.1a	< 0.0001	NS	NS

Data are presented as mean±SD, n=6. Values on the same row not sharing a common letter are significantly different. P<0.05 is considered statistically significant. ALT, alanine aminotransferase; NAFLD, non-alcoholic fatty liver disease; NS, not significant; QR, quinone reductase; TG, triglycerides; WBD, Western+Broccoli diet; WD, Western diet.

¹Percent body weight.

²Specific activity, nmol thiazolyl blue tetrazolium bromide (MTT)/min per mg protein.