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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Cell. 2016 Sep 1;166(6):1572–1584.e16. doi: 10.1016/j.cell.2016.08.006

Figure 7.

Figure 7

Model mechanism of inhibition of mRNA-dependent PGL-3 drop assembly by MEX-5. In absence of MEX-5, mRNA binds PGL-3 via the RGG repeats and increases the local concentration of PGL-3, leading to phase separation. Concentration of mRNA and PGL-3 is significantly higher in the drop phase compared to the surrounding bulk phase. In presence of MEX-5, mRNA binds preferably to MEX-5 in contrast to PGL-3 resulting in inhibition of drop assembly. mRNA molecules not bound to MEX-5 bind PGL-3 and assemble few drops. These drops may recruit few mRNA-MEX-5 complexes.