Table 1.
Comparison of baseline characteristics and clinical outcomes between low concentration homocysteine and high concentration homocysteine level groups.
| Homocysteine level | P-value | ||
|---|---|---|---|
| Low concentration <15.5 μmol/L (n=96) | High concentration ≥15.5 μmol/L (n=98) | ||
| Demographics | |||
| Age, y | 62.60±12.01 | 61.99±12.56 | 0.728 |
| Sex, male (%) | 45 (46.90) | 73 (74.50) | <0.001* |
| Risk factors | |||
| Alcohol consumption (%) | 11 (11.50) | 24 (24.50) | 0.018* |
| Current smoking status (%) | 28 (29.20) | 54 (55.10) | <0.001* |
| Hypertension (%) | 59 (61.50) | 64 (65.30) | 0.578 |
| Diabetes mellitus (%) | 29 (30.20) | 15 (15.30) | 0.013* |
| Coronary atherosclerotic cardiovascular disease (%) | 30 (31.20) | 34 (34.70) | 0.61 |
| Atrial fibrillation (%) | 9 (9.40) | 16 (16.30) | 0.149 |
| Previous stroke (%) | 26 (27.10) | 19 (19.40) | 0.204 |
| Parameters on admission | |||
| Time of thrombolysis (SD), hour | 3.21±0.98 | 3.32±0.89 | 0.421 |
| NIHSS on admission (SD) | 7.94±3.84 | 8.39±3.92 | 0.42 |
| Initial systolic blood pressure (SD), mmHg | 148.58±24.07 | 146.70±21.27 | 0.565 |
| Initial diastolic blood pressure (SD), mmHg | 86.50±11.43 | 88.06±12.50 | 0.365 |
| Stroke subtype | 0.232 | ||
| TACI (%) | 13 (13.50) | 21 (21.40) | |
| PACI (%) | 56 (58.30) | 60 (61.20) | |
| POCI (%) | 9 (9.40) | 6 (6.10) | |
| LACI (%) | 18 (18.80) | 11 (11.20) | |
| Blood test on admission | |||
| Hemoglobin level (SD), g/l | 134.78±16.24 | 140.55±19.41 | 0.03* |
| Platelets count (SD), ×109/l | 210.26±60.95 | 222.97±83.63 | 0.24 |
| Fibrinogen level (SD), g/l | 3.00±0.72 | 3.00±0.94 | 0.995 |
| Uric acid level (SD), μmol/l | 258.21±81.59 | 301.67±95.80 | <0.001* |
| Blood glucose level (SD), mmol/l | 6.36±2.35 | 6.09±2.78 | 0.485 |
| Triglyceride (SD), mmol/l | 1.57±1.00 | 1.71±1.11 | 0.377 |
| Low density lipoprotein (SD), mmol/l | 2.73±0.80 | 2.81±1.10 | 0.558 |
| High density lipoprotein(SD), mmol/l | 1.26±0.34 | 1.20±0.34 | 0.301 |
| Total cholesterol (SD), mmol/l | 4.59±1.02 | 4.78±1.32 | 0.274 |
| Outcome | |||
| sICH (%) | 2 (22.20) | 10 (76.90) | 0.027** |
| NIHSS 1 week after stroke (SD) | 4.59±5.56 | 6.72±7.70 | 0.029* |
| mRS (SD) | 1.80±1.46 | 2.41±1.71 | 0.009* |
SD – standard deviation; NIHSS – National Institutes of Health Stroke Scale; TACI – total anterior circulation infarcts; PACI – partial anterior circulation infarcts; POCI – posterior circulation infarcts; LACI – lacunar infarcts; sICH – symptomatic intracerebral hemorrhage; mRS – modified Rankin Score. An asterisk (*) indicates a significant difference between two groups at P<0.05;
**
Fisher exact test.