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. Author manuscript; available in PMC: 2017 Feb 4.
Published in final edited form as: Nature. 2016 Aug 4;536(7614):41–47. doi: 10.1038/nature18642

Extended Data Figure 6. Single variant analyses.

Extended Data Figure 6

Manhattan plot of single-variant analyses generated from a. exome sequence data in 6,504 cases and 6,436 controls of African American, East Asian, European, Hispanic, and South Asian ancestry; b. exome array genotypes in 28,305 cases and 51,549 controls of European ancestry; and c. combined meta-analysis of exome array and exome sequence samples. Coding variants are categorized according to their relationships to the previously reported lead variant from GWAS region. Loci achieving genome-wide significance only in the combined analysis are highlighted in bold. The HNF1A variant reaching genome-wide significance in the combined analysis is a synonymous variant (Thr515Thr). The dashed horizontal line in each panel designates the threshold for genome-wide significance (p<5×10−8).