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. Author manuscript; available in PMC: 2017 Feb 4.
Published in final edited form as: Nature. 2016 Aug 4;536(7614):41–47. doi: 10.1038/nature18642

Extended Data Figure 9. Exclusion of synthetic associations and construction of credible causal variant sets at T2D GWAS loci.

Extended Data Figure 9

Ten T2D GWAS loci were selected for synthetic association testing (p<0.001; Methods). a, The effect size observed at the GWAS index SNV (sequence data) before (navy blue) and after (light blue, grey) conditioning on candidate rare and low-frequency (MAF<5%) variants which could produce synthetic association. b, Example of synthetic association exclusion at the TCF7L2 locus. c, Credible sets for T2D GWAS loci where credible set consisted of <80 variants displaying the proportion of credible set variants present in the HapMap and 1000G catalogs.