Table 1.

Comparative findings of corneal stromal DL depth after CXL

Study	Patients (N)	CXL protocol	DL depth	Detection modality	Time of DL detection
Seiler and Hafezi47	16	Conventional	300 µm	Confocal microscopy	2 weeks
Doors et al51	28	Conventional	313 µm	AS-OCT	1 month
Yam et al49	40	Conventional	281 µm	AS-OCT	6 months
Filippello et al61	20	Transepithelial	100 µm	AS-OCT	2 weeks
Kymionis et al56	16	Conventional vs accelerated	351 µm; 288 µm	AS-OCT	1 month
Mazzotta et al59	20	Accelerated PL vs CL	215 µm PL; 160 µm CL	AS-OCT/confocal microscopy	1 month
Moramarco et al50	60	Accelerated PL vs CL	213 µm PL; 149 µm CL	AS-OCT	1 month
Bonnel et al64	12	Iontophoresis	247 µm	AS-OCT	1 month
Kymionis et al48	29	Conventional vs accelerated	342 µm; 313 µm	AS-OCT	1 month
Bikbova and Bikbov65	119	Conventional vs iontophoresis	292 µm; 172 µm	AS-OCT	2 weeks

Abbreviations: AS-OCT, anterior segment optical coherence tomography; CL, continuous light; CXL, collagen cross-linking; DL, demarcation line; PL, pulsed light.