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. 2016 Sep 19;11:4777–4785. doi: 10.2147/IJN.S112560

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© 2016 Rodríguez-Serrano et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Building-up of the NPs.

Notes: The union of the nanoparticle to the protein A and the antibody (Trastuzumab) are modified from Cruz-Bustos T, González-González G, Morales-Sanfrutos J, Megía-Fernández A, Santoyo-González F, Osuna A. Functionalization of immunostimulating complexes (ISCOMs) with lipid vinyl sulfones and their application in immunological techniques and therapy. Int J Nanomedicine. 2012;7:5941–5956.¹⁶ This figure was made using graphic components obtained from the website: www.somersault1824.com.

Abbreviations: NPs, nanoparticles; ISCOM, immunostimulating complex; HER2, human epidermal growth factor receptor 2.