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(A-D) Effect of 19(S)-HETE (3 μM), cicaprost (1 μM) and sodium nitroprusside (SNP) (1 mM) pretreatment of platelets on aggregation of platelets isolated from wild-type (Ptgir+/+) and IP-receptor-deficient mice (Ptgir-/-) induced by 0.1 U/ml thrombin. Shown are representative aggregation traces of at least 3 independently performed experiments.
