Table 3.
Comparison of NSAID Cases by Implicated Agent
| Feature | Diclofenac | Celecoxib | Meloxicam | Etodolac | Oxaprozin |
|---|---|---|---|---|---|
|
| |||||
| N | 16 | 3 | 3 | 2 | 2 |
|
| |||||
| Causality: | 1.9 | 2.0 | 2.3 | 2.0 | 1.5 |
| Definite | 4 | 1 | 0 | 1 | 1 |
| Very Likely | 9 | 1 | 2 | 0 | 1 |
| Probable | 3 | 1 | 1 | 1 | 0 |
|
| |||||
| Severity | 2.8 | 3.0 | 3 | 2 | 1 |
| Mild [1] | 6 | 0 | 0 | 0 | 2 |
| Mod [2,3] | 2 | 3 | 3 | 2 | 0 |
| Severe [4,5] | 8 | 0 | 0 | 0 | 0 |
|
| |||||
| Fatality | 6% | 0% | 0% | 0% | 0% |
|
| |||||
| Duration Rx | 90.1 | 58.7 | 11.0 | 211.5 | 18.0 |
|
| |||||
| Immunoallergic | 25% | 0% | 33% | 0% | 100% |
|
| |||||
| Autoimmune | 38% | 0% | 0% | 0% | 0% |
|
| |||||
| Prednisone | 38% | 33% | 33% | 0% | 50% |
|
| |||||
| ALT (initial) | 1386 | 656 | 360 | 492 | 478 |
|
| |||||
| Alk P (initial) | 182 | 319 | 901 | 235 | 228 |
|
| |||||
| Bilirubin (initial) | 8.0 | 7.4 | 12.3 | 3.9 | 0.7 |
|
| |||||
| Bilirubin (peak) | 14.8 | 11.1 | 12.3 | 4.0 | 1.4 |
|
| |||||
| INR (peak) | 1.5 | 1.1 | 1.1 | 1.1 | 1.2 |
|
| |||||
| Symptoms | 94% | 100% | 100% | 100% | 100% |
|
| |||||
| Jaundice | 69% | 100% | 100% | 100% | 50% |
|
| |||||
| Itching | 38% | 33% | 0% | 50% | 100% |
|
| |||||
| Rash | 31% | 0% | 33% | 50% | 100% |
|
| |||||
| Fever | 25% | 0% | 33% | 0% | 100% |
|
| |||||
| ANA | 31% | 0% | 0% | 0% | 50% |
|
| |||||
| ASMA | 25% | 0% | 0% | 0% | 0% |