Table 2.
Cytotoxicity (IC50, μM) of compounds against parental KB-3-1 and cisplatin-resistant B CP.5 cell lines. Cells were analyzed in 2D culture and 3D culture grown for either 1 or 4 days.
| IC50 (μM) | |||
|---|---|---|---|
|
| |||
| Culture method | 2D | 3D 1 Day | 3D 4 Day |
| Cisplatin (1) | |||
| KB-3-1 | 2.5 ± 0.1 | 4.5 ± 0.7 | 9.4 ± 0.7 |
| CP.5 | 21.0 ± 2.8 | 22.9 ± 4.6 | 32.1 ± 6.9 |
|
| |||
| [PtCl2(en)] (2) | |||
| KB-3-1 | 4.1 ± 0.2 | 21.4 ± 1.0 | 150* |
| CP.5 | 107.4 ± 10.9 | 297.7 ± 21.8 | >500 |
|
| |||
| BODIPY-Pt (9) | |||
| KB-3-1 | 36.9 ± 1.3 | 53.8 ± 7.1 | 140.9 ± 6.6 |
| CP.5 | 141.5 ± 12.5 | 185.7 ± 47.2 | 299.5 ± 92.2 |
*
single data point