Figure 1. Magnetization transfer ratio (MTR) in new gadolinium lesions.

Light lines indicate timecourses in individual lesions while heavy lines show the model predictions. The shaded gray area indicates the acute period, 3 months before and after lesion formation; this period was not included in the model, but is shown in the figure to illustrate the full MTR timecourse. Prior to lesion formation, MTR was not significantly different in glatiramer acetate (GA) (green)– and interferon-β-1b (IFN-β-1b) (blue)–treated participants. MTR dropped to a minimum around the timepoint the lesion was identified (time 0), then recovered partially. Recovery was slightly better in GA-treated participants. Random intercepts calculated by the model have been subtracted from the individual timecourses in this figure.